The Cluj–Boston Heart Science Symposium builds on the Cluj Cardiology International Workshop’s legacy by engaging cardiology residents, fellows and trainees in interactive learning alongside seasoned faculty, continuing its mission of offering young cardiologists a unique opportunity to learn about advances in cardiovascular disease from leading scholars.  The program highlights the transatlantic academic collaboration between two landmark centers of education and research. In line with global trends, a major emphasis is on digital health and AI in cardiology, reflecting how these technologies are transforming cardiovascular care. In a warm, collaborative atmosphere, basic scientists, clinician-scientists and practicing cardiologists come together to share insights and address the growing burden of cardiovascular disease amid the rapid changes in the field.